Rugiet vs Quattro: Two Sublingual ED Combinations, Compared
Both dissolve under the tongue and both combine medications. Here is exactly what is in each, what it costs, and what happens if it does not work for you.
The short version
- Both are compounded, prescription-only sublingual combinations that dissolve under the tongue.1,2
- Rugiet Ready: sildenafil + tadalafil + apomorphine, from $7.29 a dose.1,3
- Quattro: sildenafil + tadalafil + vardenafil + apomorphine, from $115 for 10 doses.2
- Refunds: Rugiet refunds only before your medication is ordered; Quattro has no money-back guarantee and charges only after a clinician approves.4
Rugiet and Quattro are built on the same idea: instead of choosing one ED medication, combine several in a single dose that dissolves under the tongue. That makes them more alike than any other pair in this category, so the details decide it.
What is in each
| Ingredient | What it does | Rugiet Ready | Quattro |
|---|---|---|---|
| Sildenafil | PDE5 inhibitor; peak about 1 hour, ~4-hour half-life5 | ✓ | ✓ |
| Tadalafil | PDE5 inhibitor; effect up to 36 hours6 | ✓ | ✓ |
| Vardenafil | PDE5 inhibitor; absorbed well in dissolving form7 | — | ✓ |
| Apomorphine | Dopamine agonist acting on arousal in the brain8 | ✓ | ✓ |
Rugiet does not list its doses on its product page and says dosing is personalized.1 Quattro's doses are also set by the prescribing clinician. The practical difference is vardenafil: Quattro includes all three PDE5 inhibitors, Rugiet two.
Price
Rugiet lists Ready from $7.29 a dose and is HSA and FSA eligible.3 Quattro starts at $115 for a 10-dose month, which works out to $11.50 a dose, with a larger pack available at a lower per-dose price.2 Both include the clinician consultation in the price.
Speed and duration
Both companies say their product works in about 15 minutes and lasts up to 36 hours; Rugiet bases its figure on a survey of 114 of its patients.1,2 Neither claim comes from a head-to-head clinical trial, and no such trial exists. What the published research does show is that sublingual and dissolving forms of PDE5 inhibitors can be absorbed somewhat faster than tablets,9,10 that tadalafil's effect lasts up to 36 hours,6 and that sublingual apomorphine produced a median time to erection of about 19 minutes in a clinical trial.8
Refunds and guarantees
Rugiet's terms say it does not offer refunds or returns except before the medication has been ordered, or if its medical provider disqualifies you.4 Quattro does not offer a money-back guarantee either; its card is charged only once a clinician approves the prescription, so a medical disqualification costs nothing.
The consult
Both start with an online questionnaire reviewed by a licensed clinician. Rugiet adds a video visit only when required and includes unlimited follow-ups.1 Quattro is prescribed by a state-licensed clinician after an asynchronous review and filled by a state-licensed 503A compounding pharmacy.2
Which to choose
If the lowest per-dose price is the priority, Rugiet starts lower. If you want all three PDE5 inhibitors in one dose, Quattro is the more complete combination. Either way, both are compounded drugs that are not FDA-approved, and a clinician needs to confirm a combination is safe for you.11
Considering Quattro?
Quattro is a compounded sublingual dose combining sildenafil, tadalafil, vardenafil and apomorphine, prescribed only after a licensed clinician reviews your health history. It starts at $115 for a 10-dose month.
See if Quattro is right for you →Sponsored. Quattro is compounded by a state-licensed 503A pharmacy for an individual patient. Compounded drugs are not FDA-approved and have not been reviewed by the FDA for safety or effectiveness. Prescription required; subject to clinician approval.
Frequently asked questions
What is the difference between Rugiet Ready and Quattro?
Both are compounded sublingual combinations. Rugiet Ready contains sildenafil, tadalafil and apomorphine. Quattro contains those three plus vardenafil.
Which is cheaper, Rugiet or Quattro?
Rugiet lists Ready from $7.29 a dose. Quattro starts at $115 for 10 doses, or $11.50 a dose. Prices vary by strength and plan.
Do Rugiet or Quattro offer refunds?
Rugiet's terms allow a refund only before the medication is ordered or if you are medically disqualified. Quattro does not offer a money-back guarantee, and its card is charged only after a clinician approves the prescription.
Sources
- Rugiet. Rugiet Ready. Accessed September 30, 2026.
- Vea Health. Quattro. Accessed September 30, 2026.
- Rugiet. Rugiet cost and pricing. Accessed September 30, 2026.
- Rugiet. Terms and conditions. Accessed September 30, 2026.
- Pfizer. VIAGRA (sildenafil citrate) prescribing information. DailyMed, U.S. National Library of Medicine.
- Eli Lilly. CIALIS (tadalafil) prescribing information. DailyMed, updated June 2026.
- Heinig R, et al. Pharmacokinetics of a new orodispersible tablet formulation of vardenafil: results of three clinical trials. Clin Drug Investig. 2011. PubMed 20925442.
- Dula E, et al. Double-blind, crossover comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL. Eur Urol. 2001. PubMed 11464037.
- De Toni L, et al. Sublingual administration of sildenafil oro-dispersible film. Front Pharmacol. 2018. PubMed 29467656.
- Sangkum P, et al. Efficacy of the orally disintegrating strip sildenafil: a prospective, randomized trial. Sex Med. 2021. PubMed 34710784.
- U.S. Food and Drug Administration. Compounding and the FDA: Questions and Answers.
Advertising disclosure. Men's Health Insider is published in partnership with Vea Health, which makes Quattro, one of the products covered on this site. We may earn compensation when readers buy through links here. We say so on every page where it applies, and it never changes what our sources say. Nothing on this site is medical advice; a licensed clinician should decide what is right for you.